From Germs to Mammals in Aqua
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SCOPUS 2020
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Genetics of Aquatic Organisms 2021, Vol 5, Num, 2     (Pages: 87-93)

In Silico Prediction of Molecular Interaction Within PmCBP-VP24 Complex to Understand Initial Instigation of WSSV into Shrimps

Kanika Yadav 1 ,Arunima Kumar Verma 2 ,Ajey Kumar Pathak 3 ,Abhishek Awasthi 1

1 Maharaja Agrasen University, Department of Biotechnology, Baddi, Solan, Himachal Pradesh India
2 Autonomous Government P.G. College, Department of Zoology, Satna, Madhya Pradesh, India
3 Fish Conservation Division, National Bureau of Fish Genetic Resources, Lucknow, Uttar Pradesh, India
DOI : 10.4194/2459-1831-v5_2_05 Viewed : 70 - Downloaded : 69 White Spot Disease is one of the most devastating diseases of shrimps. Molecular interaction between shrimp receptor protein PmCBP (Chitin binding protein of Peneaus monodon) and viral envelop protein VP24 is obligatory for binding of the White Spot Syndrome Virus to the shrimp digestive tract, and failure of this anchoring leads to an ineffectual infection. This is a first study that throws light on the molecular interaction of PmCBP-VP24 complex and provides important clues for initial steps of ingression of the virus into shrimps. Keywords : White Spot Disease (WSD), White Spot Syndrome Virus (WSSV), PmCBP-VP24 complex, Viral entry